It all depends on the level of humidity control you need. It is common to run the dehumidifier through the spring-fall, with heavy use during the summer if it is hot, muggy, and humid. This can vary on the area/region you live in.
* If you live in a northern climate and it gets cold in the winter, the air typically gets dry, so you do not need to run it all year-round. During this time, it is best to unplug and stow away the unit as colder weather could do harm to the appliance itself. Royal Sovereign Dehumidifiers should not be operated in temperatures under 41°F to prevent the coils from freezing and causing damage.
* If you live in a southern climate that does not get cold in the winter, you will need to monitor when to use the dehumidifier throughout the year. If you use an air conditioner all year-round it can limit the need for a dehumidifier, as A/C naturally lowers humidity because it cycles air through its condenser and evaporator coil. If it is hot outside and humid, an air conditioner alone could be very effective, however a dehumidifier is useful in when the temperature is not that high, but the humidity is.
* In specific locations that are prone to dampness such as cellars or basements, you may have to run the unit all year-round.